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Current Clinical Trials


For information about cancer clinical trials, click here.


 Study Name Purpose
Arrhythmias

ARTESIA

 

A double-blind randomized controlled trial to determine if pts with device-detected sub-clinical AF when treated with apixaban compared with aspirin will reduce embolism risk.  To learn more about this study, click here.   

Genetic-AF

This study is being done to compare the effects of Bucindolol to Toprol-XL on the recurrence of symptomatic atrial fibrillation/atrial flutter in patients with heart failure who have a specific genotype for the beta-1 adrenergic receptor.  To learn more about this study, click here.

MRI Protocol

 

To accumulate pre-and post-scan device interrogation data for the purpose of determining the risk of MRI for patients with implantable devices.

Product Surveillance
Registry

 

Collects long-term follow-up information on Medtronic pacemakers, ICDs and CRTs to monitor safety and performance. To learn more about this study, click here.

Bariatric

FitBit Healthy Weight

 

Determine if Fitbit is associated with improved health outcomes in Healthy Weight Management patients that pursue sleeve gastrectomy surgery. To learn more about the study, click here.

Coronary Artery Disease (CAD)

APO(a)-LRx

 

Evaluate the safety of ISIS 681257 for reduction of plasma Lp(a) levels in patients with hyperlipoproteinemia(a) and established cardiovascular disease (CVD).  To learn more about the study, click here.  

AUGUSTUS

 

To evaluate the safety of Apixaban vs. Vitamin K antagonist and aspirin vs. aspirin placebo in patients with atrial fibrillation in acute coronary syndrome or percutaneous coronary intervention. 

CT Perfusion

 

To monitor the safety and efficiency of the myocardial CT Perfusion procedure following a cardiac CT at a community hospital.

Shield II

 

Evaluate the HeartMate PHP System indicated for use during high risk PCI performed in hemodynamically stable patients with severe CAD and depressed EF.  To learn more about this study, click here.

Heart Failure

AdaptResponse

 

Evaluate the AdaptivCRT algorithm outcome against standard CRT devices in subjects with normal AV conduction and left bundle branch block.  To learn more about the study, click here.

Athena (HFN)

Evaluate aldosterone targeted neurohormonal combined with natiuresis therapy in acute heart failure.  To learn more about the study, click here.

BeAT HF

The purpose of this clinical investigation is to evaluate the efficacy and safety of the CVRx Barostim Neo System vagal nerve stimulation in the treatment heart failure.  To learn more about the study, click here.

Cardiomems PAS

Evaluate the safety and efficacy of Cardiomems Heart Failure System in patients with NYHA Class III heart failure in a commercial setting.  To learn more about this study, click here.

CHF FitBit

Determine if monitored activity and aggressive mobility provides improved outcomes in hospitalized heart failure patients.  To learn more about this study, click here.

Galactic HF

Determine if omecamtiv mecarbil/AMG 423 when added to standard of care medications is well tolerated and superior to placebo in reducing the risk of cardiovascular death or heart failure events in subjects with an ejection fraction < 35%.  To learn more about the study, click here.

HEART-FID

Determine the efficacy and safety of iron therapy using IV ferric carboxymaltose, relative to placebo, in the treatment of participants with iron deficiency, heart failure, and an ejection fraction of < 35%.  To learn more about the study, click here.

Relax-AHF2

Randomized, double-blind, placebo controlled study to evaluate the efficacy, safety and tolerability of Serelaxin when added to standard therapy in acute heart failure patients.  To learn more about the study, click here.

RESPOND

To evaluate the impact of Rate Adaptive Pacing on exercise time on a treadmill guided by respiratory exchange ratio during Cardio Pulmonary Exercise Test.

REVAMP

The primary objective is to assess the feasibility of using elevated night pacing as a therapy for heart failure with preserved ejection fraction.

Smile

To determine if a decrease in HF re-hospitalizations occurs during f/u period when ReDS guided treatment is used as an adjunct to SOC.  To learn more about the study, click here.

Hyperlipdemia

Cascade FH

 

Track trends in therapy, events and outcomes in FH patients.  To improve the care, quality of life and survival of those with FH.  To learn more about the study, click here.

IN-TANDEM

Integrating active Familial Hypercholesterolemia (FH) case-finding with next-generation genetic sequencing for diagnosis through electronic health records (EPIC) using Find FH algorithm.

Maternal and Fetal Health

 

 

No active studies.

Nephrology

ASCEND-ND

 

Safety and efficacy of daprodustat compared to darbepotien alfpha in non-dialys (ND) patients with anemia associated with chronic kidney disease. To learn more about the study, click here.

Lupus Nephritis

 

Safety and tolerability of multiple rising does of ixazomib citrate for the treatment of patients with Lupus Nephritis.  To learn more about the study, click here.

Neurology

Stroke AF

 

Compare the incidence of AF with Reveal LINQ (monitor arm) and SOC medical treatment (control arm) in recent ischemic stroke subjects of presumed known origin.  To learn more about the study, click here.

Pulmonary Hypertension

Lariat

 

A Dose-ranging Study of the Efficacy and Safety of Bardoxolone Methyl in Patients with Pulmonary Arterial Hypertension.  To learn more about the study, click here.

INCREASE (Tyvaso)

 

To evaluate the safety and efficacy of inhaled treprostinil in subjects with pre-capillary PH associated with ILD including combined pulmonary fibrosis and CPFE.  To learn more about the study, click here.

SOUTHPAW

 

To evaluate the effect of oral treprostinil versus placebo on change in exercise capacity as measured by 6MWD from Baseline to 24 wk. in subjects with pulmonary hypertension associated with heart failure and an ejection fraction of <35%.  To learn more about the study, click here.  

Valve

MRI-MVS

 

To assess severity of MR by MRI in patients for mitral valve surgery.  Access cost, QOL, post-surgery outcomes, likelihood of valve replacement vs. repair.  To learn more about the study, click here.  




 

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