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Current Clinical Trials


For information about cancer clinical trials, click here.


 Study Name Purpose
Arrhythmias

AUGUSTUS

 

To evaluate the safety of Apixaban vs. Vitamin K antagonist and aspirin vs. aspirin placebo in patients with atrial fibrillation in acute coronary syndrome or percutaneous coronary intervention. 

Genetic-AF

This study is being done to compare the effects of Bucindolol to Toprol-XL on the recurrence of symptomatic atrial fibrillation/atrial flutter in patients with heart failure who have a specific genotype for the beta-1 adrenergic receptor.  To learn more about this study, click here.

Coronary Artery Disease (CAD)

ARTEMIS

 

A multicenter, cluster- randomized clinical trial to assess the impact of copayment reduction by equalizing the copayment of clopidogrel and ticagrelor.  To learn more about this study, click here.

CT Perfusion

 

To monitor the safety and efficiency of the myocardial CT Perfusion procedure following a cardiac CT at a community hospital.

Shield II

 

Evaluate the HeartMate PHP System indicated for use during high risk PCI performed in hemodynamically stable patients with severe CAD and depressed EF.  To learn more about this study, click here.

Devices

BeAT HF

 

The purpose of this clinical investigation is to evaluate the efficacy and safety of the CVRx Barostim Neo System vagal nerve stimulation in the treatment heart failure.  To learn more about the study, click here.

Cardiomems PAS

Evaluate the safety and efficacy of Cardiomems Heart Failure System in patients with NYHA Class III heart failure in a commercial setting.  To learn more about this study, click here.

Linq HF

A premarket study evaluating Reveal Linq data from HF patients against subsequent acute decompensated heart failure events.

Micra

Evaluate the safety and efficacy of Medtronic leadless single chamber pacemaker.  To learn more about this study, click here.

MRI Protocol

To accumulate pre-and post-scan device interrogation data for the purpose of determining the risk of MRI for patients with implantable devices.  To learn more about this study, click here.

OptiSure

Evaluate the chronic performance of the St. Jude Medical Optisure family of high voltage leads in patients.  To learn more about the study, click here.

Parachute HF

Evaluate percutaneous catheter-based structural restoration Rx in patients with ischemic heart failure.  To learn more about the study, click here.

Product
Surveillance
Registry

 

Collects long-term follow-up information on Medtronic pacemakers, ICDs and CRTs to monitor safety and performance. To learn more about this study, click here.

Quartet 1457Q

 

Evaluate the safety and efficacy of the St Jude Medical left ventricular quadrapolar lead. To learn more about the study, click here.

Heart Failure

AdaptResponse

 

Evaluate the AdaptivCRT algorithm outcome against standard CRT devices in subjects with normal AV conduction and left bundle branch block.  To learn more about the study, click here.

Athena (HFN)

Evaluate aldosterone targeted neurohormonal combined with natiuresis therapy in acute heart failure.  To learn more about the study, click here.

Relax-AHF2

Randomized, double-blind, placebo controlled study to evaluate the efficacy, safety and tolerability of Serelaxin when added to standard therapy in acute heart failure patients.  To learn more about the study, click here.

Smile

To determine if a decrease in HF re-hospitalizations occurs during f/u period when ReDS guided treatment is used as an adjunct to SOC.  To learn more about the study, click here.

Hyperlipdemia

Cascade FH

 

Track trends in therapy, events and outcomes in FH patients.  To improve the care, quality of life and survival of those with FH.  To learn more about the study, click here.

Process vs. Outcomes

Randomized controlled trial to evaluate the effectiveness of improving LDL values using process vs. outcomes financial incentives.  To learn more about the study, click here.

Maternal and Fetal Health

ARIOS

 

To assess the safety and outcomes of infants and children who were exposed to retosiban or comparator in utero in the Newborn-1 study.  To learn more about the study, click here.

IMPLICIT 

 

Interventions for preventing low birthweight infants in family medicine populations in PA.

Newborn-1

 

The study's primary objective is to demonstrate the superiority of retosiban to prolong pregnancy and improve neonatal outcomes compared with placebo.  To learn more about the study, click here.

Nephrology

Lupus Nephritis

 

Safety and tolerability of multiple rising does of ixazomib citrate for the treatment of patients with Lupus Nephritis.  To learn more about the study, click here.

Pulmonary Hypertension

Lariat

 

A Dose-ranging Study of the Efficacy and Safety of Bardoxolone Methyl in Patients with Pulmonary Arterial Hypertension.  To learn more about the study, click here.

Tyvaso

 

To evaluate the safety and efficacy of inhaled treprostinil in subjects with pre-capillary PH associated with ILD including combined pulmonary fibrosis and CPFE.  To learn more about the study, click here.




 

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