Lupus and Antiphospholipid Antibody Syndrome

Topic Overview

About 1 out of 3 people withlupusproduce anantibodythat attacks certain blood-clotting factors, which can cause the blood to clot easily.footnote 1A person who has this antibody and has had blood clots is said to have antiphospholipid antibody syndrome. This can lead to mild or severe blood-clotting complications, including:

A blood test can detect antiphospholipid antibodies. When diagnosed, the condition is usually treated withanticoagulants. Pregnant women with antiphospholipid antibody syndrome need to be closely monitored.



  1. Crow MK (2016). Systemic lupus erythematosus. In L Goldman, A Shafer, eds., Goldman-Cecil Medicine, 24th ed., vol. 2, pp. 1769-1777. Philadelphia: Saunders.


ByHealthwise Staff
Primary Medical ReviewerAnne C. Poinier, MD - Internal Medicine
Martin J. Gabica, MD - Family Medicine
E. Gregory Thompson, MD - Internal Medicine
Kathleen Romito, MD - Family Medicine
Specialist Medical ReviewerNancy Ann Shadick, MD, MPH - Rheumatology

Current as ofOctober 10, 2017